BASF Metabolome Solutions GmbH

Our Services for Your Business

We deliver mass spectrometry (MS)-based metabolite and protein analytics, data interpretation as well as plant testing capabilities under GLP and GLP-like quality standards to BASF operating divisions, corporate research projects and external customers.

Next Generation Metabolite Profiling

BASF Metabolome Solutions is the leading industry expert in Metabolite Profiling. Also coined Metabolomics, this is the broad measurement of chemical compositions of biological systems used as the most comprehensive display of changes in the “chemistry of life” in an organism. In the last two decades the technology has shown to be of high value to the industry by supporting product innovations in the agricultural, health and biotechnology sector.

Critical know-how and utmost focus to operational quality are essential to successfully utilize Metabolite Profiling. BASF Metabolome Solutions GmbH has more than 24 years of expertise in value added Metabolite Profiling applications, supporting BASF and customers from pharmaceutical, health and nutrition industries.

We are offering our expertise to clients in the industry to support innovation. Please contact us with your task for metabolite profiling in any biological system.

Targeted metabolite analytics

Where the target area of metabolism is known more specifically, we offer targeted analytics of high sensitivity to quantify individual or groups of metabolites even more efficiently. As an example, our highly sensitive steroid and catecholamine hormone profiles are applied in high throughput to add these important data to MetaMap^® Tox.

With the expertise of hundrets of analytical methods developed for plant, animal and microbial matrices, we are confident in solving even challenging analytical tasks. You can choose from our wide portfolio of target methods in plant, animal and microbial matrices or request a tailored development and validation of a new method for your specific needs.

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MetaMap^®Tox Metabolome Database

MetaMap^®Tox is a database of metabolome profiles built over more than 18 years by BASF SE and BASF Metabolome Solutions GmbH in order to enable toxicity prediction of new compounds and to study their respective modes of actions.

The database provides the algorithms to analyze the metabolomic data in various ways such as overall comparison of significantly changed metabolites including statistical analyses, pattern ranking and treatment correlations. New compounds can be compared to more than 1000 other treatments with different modes of action and to over 110 patterns indicative of specific target organ toxicities.

We are eager to validate the MetaMap^®Tox database, the world’s largest consistent repository of Metabolite Profiling data to refine and reduce animal testing, as a new standard for read-across data in toxicological assessments.

Learn more about MetaMap^®Tox:

Compound analytics

We quantify the chemical residue or metabolites of chemicals in any biological matrix according to OECD / SANCO standards - where required under GLP compliance. Examples are quantification of administered compounds in plasma of test animals, or biokinetic (ADME) studies of agrochemicals in plants – including sample generation in our greenhouse where needed. We also offer to identify typical phase 1 and phase 2 metabolites of chemicals in biological systems. Please contact us and we will bring in all our expertise to find a solution to your challenge.

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Protein MS analytics

BASF Metabolome Solutions GmbH uses high resolution LC-MS/MS analytics to identify and quantify proteins and peptides of interest in complex biological and non-biological (e.g. detergents) matrices. The technology only requires knowledge of the desired protein or peptide sequence of interest. It can also resolve post translational modifications. With this approach, cumbersome antibody generation or ELISA development become obsolete. As all our services, protein and peptide analytics can be performed under GLP compliance, where necessary.

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Plant Services

In our growth chamber facility we grow, transform and screen model plants like Arabidopsis thaliana as well as crop plants under high precision climate-controlled conditions. Facilities are operated under strict stewardship rules and in compliance to the German Gentechnikverordnung. Our tailored solutions to reproducibly spray crop protection compounds are covering applications from single plants to entire tables to address any research and regulatory question.

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Metabolome Data Science

As metabolome data scientists with expertise in biochemistry, systems biology, and biomarker identification, we have a strong track record in extracting and interpreting the most relevant findings from multidimensional metabolite profiling and other “omics” data.
Having successfully translated such information into value-adding industrial applications in plant research, white biotechlogy, toxicology, human nutrition and disease for more than two decades, we are confident that teaming up your experts in the field with our data scientists will help advancing your projects.
Please contact us to discuss statistical experiment planning, data analysis options and best possible integration of your existing and/or jointly generated metadata.