BASF Metabolome Solutions GmbH
Treatment Correlation
The treatment correlation compares the metabolome profile of a test substance with the metabolome profiles of all other substances in the MetaMap® Tox database by using Pearson and Spearman correlation. This has the aim to identify substances that show a similarity to other substances regarding their metabolome profile.
After choosing the respective study and substance, the dose, sex and time point of blood taking, the calculation is conducted. As a result of the comparison, the treatment correlation gives the profile strength (which represents the rounded down average of absolute medians of t-values and includes the absolute number of changed metabolites but also the magnitude of the respective change), the Pearson and the Spearman correlation, the respective p values, as well as the corresponding rank. Also, the number of common metabolites between the test and target treatment is given. The Pearson and Spearman correlation give the connection between two variables.
Figure 4: Treatment correlation
Correlation of a treatment against all other treatments in the MetaMap® Tox database and ranking according to Pearson or Spearman correlation (screenshot).