BASF Metabolome Solutions GmbH
Videos
Here we present some videos demonstrating the utilization of the MetaMap® Tox database in various case studies.
Metabolomics as read-across tool: A case study with phenoxy herbicides
In this video we show how metabolomics can address chemical grouping and read across from a biological perspective by utilizing the MetaMap® Tox database. Therefore, we present a case study for phenoxy herbicides for which we applied read-across and selected Mecoprop-p (MCPP) as target substance and MCPA and Dichlorprop-p (2,4-DP) as source substances with the goal to waive a 90-day study with MCPP. By using metabolomics on blood samples from a 28-day study and utilizing the MetaMap® Tox database, we show how biological data can substantiate read-across.
(van Ravenzwaay et al., (2016) Metabolomics as read-across tool: A case study with phenoxy herbicides. Regul. Toxicol. Pharmacol. 81:288-304)
(van Ravenzwaay et al., (2016) Metabolomics as read-across tool: A case study with phenoxy herbicides. Regul. Toxicol. Pharmacol. 81:288-304)