BASF Metabolome Solutions GmbH
Selected MetaMap® Tox Publications
2022
Murali A, Giri V, Zickgraf FM, Ternes P, Cameron HJ, Sperber S, Haake V, Driemert P, Kamp H, Funk-Weyer D, Sturla SJ, Rietjens IMCM, van Ravenzwaay B (2023): Connecting gut microbial diversity with plasma metabolome and fecal bile acid changes induced by the antibiotics tobramycin and colistin sulfate. Chemical Research in Toxicology 36: 598-616. doi: 10.1021/acs.chemrestox.2c00316
Murali A, Zickgraf FM, Ternes P, Giri V, Cameron HJ, Sperber S, Haake V, Driemert P, Kamp H, Weyer DF, Sturla SJ, Rietjens IMGM, van Ravenzwaay B (2023): Gut microbiota as well as metabolomes of Wistar rats recover within two weeks after doripenem antibiotic treatment. Microorganisms 11: 533. doi: 10.3390/microorganisms11020533
Ramirez-Hincapie S, Birk B, Ternes P, Giri V, Haake V, Herold M, Zickgraf FM, Verlohner A, Huener H.-A., Kamp H, Driemert P, Landsiedel R, Richling E, Funk-Weyer D, van Ravenzwaay B (2023): A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity. Cell Biology and Toxicology. 2023 May 4. doi: 10.1007/s10565-023-09809-6
Wilhelmi P, Giri V, Zickgraf FM, Haake V, Henkes S, Driemert P, Michaelis P, Busch W, Scholz S, Flick B, Barenys M, Birk B, Kamp H, Landsiedel R, Funk-Weyer D (2023): A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil. Chemico-Biological Interactions 382: 110565. doi: 10.1016/j.cbi.2023.110565
2022
Landsiedel R, Hahn D, Ossig R, Ritz S, Sauer L, Buesen R, Rehm S, Wohlleben W, Groeters S, Strauss, V, Sperber S, Wami H, Dobrindt U, Prior K, Harmsen D, van Ravenzwaay B, Schnekenburger J (2022): Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects. Particle and Fibre Toxicology 19:21. https://doi.org/10.1186/s12989-022-00459-w
Murali A, Giri V, Cameron HJ, Sperber S, Zickgraf FM, Haake V, Driemert P, Walk T, Kamp H, Rietjens IMCM, van Ravenzwaay B (2022): Investigating the gut microbiome and metabolome following treatment with artificial sweeteners acesulfame potassium and saccharin in young adult Wistar rats. Food and Chemical Toxicology 165, https://doi.org/10.1016/j.fct.2022.113123
2021
Kamp H, Wahrheit J, Stinchcombe S, Walk T, Stauber F, van Ravenzwaay B (2021): Succinate dehydrogenase inhibitors: in silico flux analysis and in vivo metabolomics investigations show no severe metabolic consequences for rats and humans. Food and Chemical Toxicology 150, 112085. https://doi.org/10.1016/j.fct.2021.112085
Murali A, Giri V, Cameron HJ, Behr C, Sperber S, Kamp H, Walk T, van Ravenzwaay B (2021): Elucidating the Relations between Gut Bacterial Composition and the Plasma and Fecal Metabolomes of Antibiotic Treated Wistar Rats. Microbiology Research 12, 82-122. https://doi.org/10.3390/microbiolres12010008
2020
de Bruijn V, Behr C, Sperber S, Walk T, Ternes P, Slopianka M, Haake V, Beekmann K, van Ravenzwaay B (2020): Antibiotic-induced changes in microbiome-related metabolites and bile acids in rat plasma. Metabolites 10, 242. doi: 10.3390/metabo10060242
2019
Behr C, Slopianka M, Haake V, Strauss V, Sperber S, Kamp H, Walk T, Beekmann K, Rietjens IMCM, van Ravenzwaay B (2019): Analysis of metabolome changes in the bile acid pool in feces and plasma of antibiotic-treated rats. Toxicology and Applied Pharmacology 363, 79-87.
Keller J, Mellert W, Sperber S, Kamp H, Jiang X, Fabian E, Herold M, Walk T, Strauss V, van Ravenzwaay B (2019): Added value of plasma metabolomics to describe maternal effects in rat maternal and prenatal toxicity studies. Toxicology Letters 301, 42-52.
Sperber S, Wahl M, Berger F, Kamp H, Lemke O, Starck V, Walk T, Spitzer M, van Ravenzwaay B (2019): Metabolomics as read-across tool: An example with 3-aminopropanol and 2-aminoethanol. Regulatory Toxicology and Pharmacology 108,104442. doi:10.1016/j.yrtph.2019.104442
2018
Behr C, Sperber S, Jiang X, Strauss V, Kamp H, Walk T, Herold M, Beekmann K, Rietjens IMCM, van Ravenzwaay B (2018): Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics. Toxicology and Applied Pharmacology 355, 198-210.
Behr C, Ramirez-Hincapie S, Cameron HJ, Strauss V, Walk T, Herold M, Beekmann K, Rietjens IMCM, van Ravenzwaay B (2018): Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces. Toxicology Letters 296, 139-151.
Langsch A, David RM, Schneider S, Sperber S, Haake V, Kamp H, Leibold E, van Ravenzwaay B, Otter R (2018): Hexamoll® DINCH: Lack of in vivo evidence for obesogenic properties. Toxicology Letters 288, 99-110.
Ramirez T, Strigun A, Verlohner A, Huener HA, Peter E, Herold M, Bordag N, Mellert W, Walk T, Spitzer M, Jiang XQ, Sperber S, Hofmann T, Hartung T, Kamp H, van Ravenzwaay B (2018): Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells. Archives of Toxicology 92, 893-906.
Sperber S, Birk B, Haake V, Walk T, van Ravenzwaay B, Kamp H (2018): Differentiation of hepatotoxic compounds by metabolomics in HepG2 cells. Toxicology Letters 295, S123-S124.
2017
Behr C, Kamp H, Fabian E, Krennrich G, Mellert W, Peter E, Strauss V, Walk T, Rietjens I, van Ravenzwaay B (2017): Gut microbiome-related metabolic changes in plasma of antibiotic-treated rats. Archives of Toxicology 91, 3439-3454.
2016
Fabian E, Bordag N, Herold M, Kamp H, Krennrich G, Looser R, Ma-Hock L, Mellert W, Montoya Parra G, Peter E, Prokudin A, Spitzer M, Strauss V, Walk T, Zbranek R, van Ravenzwaay B (2016): Metabolite profiles of rats in repeated dose toxicological studies after oral and inhalative exposure. Toxicology Letters 255, 11-23.
van Ravenzwaay B, Sperber S, Lemke O, Fabian E, Faulhammer F, Kamp H, Mellert W, Strauss V, Strigun A, Peter E, Spitzer M, Walk T (2016): Metabolomics as read-across tool: A case study with phenoxy herbicides. Regulatory Toxicology and Pharmacology 81, 288-304.
2015
Buesen R, Schulte S, Strauss V, Treumann S, Becker M, Gröters S, Carvalho S, van Ravenzwaay B (2015): Safety assessment of [3S, 3'S]-astaxanthin – Subchronic toxicity study in rats. Food and Chemical Toxicology 81, 129-136.
Kamp H, Fabian E, Frericks M, Herold M, Krennrich G, Looser R, Mellert W, Montoya Parra G, Peter E, Ramirez T, Spitzer M, Strauss V, Strigun A, Walk T, van Ravenzwaay B (2015): 10 years of metabolomics research: The importance of quality control. Toxicology Letters 238, S37-S37.
Montoya Parra G, Strauss V, Kamp H, Fabian E, Herold M, Krennrich G, Looser R, Mellert W, Peter E, Spitzer M, Walk T, van Ravenzwaay B (2015): Metabolome differences in pregnancy and lactation compared to non-pregnant Wistar rats. Toxicology Letters 238, S229-S229.
van Ravenzwaay B, Kamp H, Montoya Parra GA, Strauss V, Fabian E, Mellert W, Krennrich G, Walk T, Peter E, Looser R, Herold M (2015): The development of a database for metabolomics – looking back on ten years of experience. International Journal of Biotechnology 14, 47-68.
2014
Mattes W, Davis K, Fabian E, Greenhaw J, Herold M, Looser R, Mellert W, Groeters S, Marxfeld H, Moeller N, Montoya Parra G, Prokoudine A, van Ravenzwaay B, Strauss V, Walk T, Kamp H (2014): Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. Toxicology Letters 230, 467-478.
Mattes W, Kamp H, Strauss V, Fabian E, Montoya Parra G, Mellert W, Moeller N, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2014): Metabolic profiling of hepatotoxic compounds in rats: relationship of predicted rodent to reported human phenotype. International Journal of Toxicology 33, 43-43.
Montoya Parra GA, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2014a): Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance. Toxicology Letters 225, 240-251.
Montoya Parra GA, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2014b): Qualitative and quantitative comparison of toxicological properties of racemates and their enantiomers with metabolomics. Toxicology Letters 229, S232-S232.
Montoya Parra GA, Strauss V, Kamp H, Fabian E, Herold M, Krennrich G, Looser R, Mellert W, Peter E, Walk T, van Ravenzwaay B (2014): Sex-dependent metabolome changes in rats in response to different caloric intake. Toxicology Letters 229, S232-S232.
van Ravenzwaay B, Montoya Parra GA, Fabian E, Herold M, Krennrich G, Looser R, Mellert W, Peter E, Strauss V, Walk T, Kamp H (2014): The sensitivity of metabolomics versus classical regulatory toxicology from a NOAEL perspective. Toxicology Letters 227, 20-28.
2013
Mattes W, Kamp H, Fabian E, Herold M, Krennrich G, Looser R, Mellert W, Prokoudine A, Strauss V, van Ravenzwaay B, Walk T, Naraoka H, Omura K, Schuppe-Koistinen I, Nadanaciva S, Bush ED, Moeller N, Ruiz Noppinger P, Piccoli SP (2013): Prediction of clinically relevant safety signals of nephrotoxicity through plasma metabolite profiling. BioMed Research International, 202497. doi: 10.1155/2013/202497
Mattes W, van Ravenzwaay B, Moeller N, Walk T, Ruiz Noppinger P, Kamp H (2013): Detection of idiosyncratic hepatotoxicity potential with metabolite profiling. International Journal of Toxicology 32, 70-71.
Montoya Parra G, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2013a): Mechanistic explanation of different metabolomics patterns in rat plasma for the differentiation of direct thyroid hormone synthesis inhibitors and compounds increasing thyroid hormone clearance. Toxicology Letters 221, S193-S194.
Montoya Parra G, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2013b): Amiodarone: A metabolomic approach of different modes of action (MOAs) in rats. Toxicology Letters 221, S193-S193.
Ramirez T, Bordag N, Mellert W, Kamp H, Walk T, Looser R, van Ravenzwaay B (2013): Application of metabolomics in vitro for identification of toxicological modes of action. Toxicology Letters 221, S194-S194.
van Ravenzwaay B, Herold M, Kamp H, Montoya Parra G, Fabian E, Looser R, Krennrich G, Mellert W, Prokoudine A, Strauss V, Walk T, Wiemer J (2013): Metabolomics and REACH: quantitative biological activity relationships. Toxicology Letters 221, S27-S27.
van Ravenzwaay B, Kolle S, Ramirez T, Kamp H (2013): Vinclozolin: A case study on the identification of endocrine active substances in the past and a future perspective. Toxicology Letters 223, 271-279.
2012
Kamp H, Fabian E, Groeters S, Herold M, Krennrich G, Looser R, Mattes W, Mellert W, Prokoudine A, Ruiz Noppinger P, Strauss V, Walk T, Wiemer J, van Ravenzwaay B (2012): Application of in vivo metabolomics to preclinical/toxicological studies: case study on phenytoin-induced systemic toxicity. Bioanalysis 4, 2291-2301.
Kamp H, Fabian E, Krennrich G, Leibold E, Mellert W, Strauss V, van Ravenzwaay B, Ahlbory-Dieker D, Herold M, Looser R, Prokoudine A, Walk T, Wiemer J (2012): The use of metabolomics in vivo for the development of agrochemical products. In: Jeschke P, Krämer W, Schirmer U, Witschel M (eds.): Modern Methods in Crop Protection Research. pp. 335-349. Wiley-VCH.
Kamp H, Strauss V, Wiemer J, Leibold E, Walk T, Mellert W, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M, van Ravenzwaay B (2012): Reproducibility and robustness of metabolome analysis in rat plasma of 28-day repeated dose toxicity studies. Toxicology Letters 215, 143-149.
Kolle SN, Ramirez T, Kamp H, Buesen R, Flick B, Strauss V, van Ravenzwaay B (2012): A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids. Regulatory Toxicology and Pharmacology 63, 259-278.
Ramirez T, Ahlbory-Dieker D, Fux E, Kamp H, Walk T, Wagner S, Looser R, van Ravenzwaay B (2012): Identification of liver toxicity by combining in vitro cell systems and metabolomics. Toxicology Letters 211, S160-S160.
Strauss V, Mellert W, Wiemer J, Leibold E, Kamp H, Walk T, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M, van Ravenzwaay B (2012): Increased toxicity when fibrates and statins are administered in combination – A metabolomics approach with rats. Toxicology Letters 211, 187-200.
van Ravenzwaay B, Fabian E, Herold M, Kamp H, Looser R, Mellert W, Strauss V, Walk T, Wiemer J (2012): The identification of hypothyroid effects of amiodarone by metabolomics. Toxicology Letters 211, S160-S160.
van Ravenzwaay B, Herold M, Kamp H, Kapp MD, Fabian E, Looser R, Krennrich G, Mellert W, Prokoudine A, Strauss V, Walk T, Wiemer J (2012): Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals – From QSAR to QBAR. Mutation Research / Genetic Toxicology and Environmental Mutagenesis 746, 144-150.
2011
Balcke GU, Kolle S, Kamp H, Bethan B, Looser R, Wagner S, Landsiedel R, van Ravenzwaay B (2011): Linking energy metabolism to dysfunctions in mitochondrial respiration – A metabolomics in vitro approach. Toxicology Letters 203, 200-209.
Mellert W, Kapp M, Strauss V, Wiemer J, Kamp H, Walk T, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M, van Ravenzwaay B (2011): Nutritional impact on the plasma metabolome of rats. Toxicology Letters 207, 173-181.
2010
van Ravenzwaay B, Cunha GC-P, Fabian E, Herold M, Kamp H, Krennrich G, Krotzky A, Leibold E, Looser R, Mellert W, Prokoudine A, Strauss V, Trethewey R, Walk T, Wiemer J (2010): The use of metabolomics in cancer research. In: Cho WCS (ed.): An Omics Perspective on Cancer Research. pp 141-166. Springer, Dordrecht.
van Ravenzwaay B, Cunha GC-P, Strauss V, Wiemer J, Leibold E, Kamp H, Walk T, Mellert W, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M (2010): The individual and combined metabolite profiles (metabolomics) of dibutylphthalate and di(2-ethylhexyl)phthalate following a 28-day dietary exposure in rats. Toxicology Letters 198, 159-170.
2009
Kamp H, Buesen R, Cunha GC-P, Fabian E, Fischer W, Herold M, Leibold E, Looser R, Krennrich G, Mellert W, Nishino T, Prokoudine A, Strauss V, Walk T, Wiemer J, van Ravenzwaay B (2009): Metabolite profiling – A new tool for the identification of toxicological effects of chemicals. Toxicology Letters 189, S31-S32.
Strauss V, Wiemer J, Leibold E, Kamp H, Walk T, Mellert W, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M, van Ravenzwaay B (2009): Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies. Toxicology Letters 191, 88-95.
2007
van Ravenzwaay B, Cunha GC-P, Leibold E, Looser R, Mellert W, Prokoudine A, Walk T, Wiemer J (2007): The use of metabolomics for the discovery of new biomarkers of effect. Toxicology Letters 172, 21-28.